Frequently Asked Questions

Ketamine therapy is most commonly used to treat depression, anxiety, PTSD, and certain mood disorders. Ketamine therapy also improves cognitive skills and enhances creativity and problem-solving in many individuals.

Ketamine targets the neurotransmitter glutamate, acting quickly on the areas of the brain involved in mood regulation. It also enhances neuroplasticity, allowing the brain to form new connections, reframe negative thought patterns, and improve overall mental well-being, leading to long-lasting benefits.

Over time, repeated use of Horizon-range ketamine encourages positive changes in the brain that support clarity around your thoughts, feelings, and behavior. This allows you to develop greater self-awareness and emotional resilience, supporting more authentic connections with other people. Practices such as journaling and meditation can help integrate the insights provided during ketamine treatments, supporting deeper healing and lasting change.

The Horizon dose range is lower than high-dose ketamine treatments requiring supervision. However, Horizon dosing differs from very low doses because it provides deeper therapeutic benefits while maintaining comfort and clarity. While microdosing provides subtle support, the Horizon approach unlocks more profound healing potential that can lead to more obvious benefits.

Like higher-dose, at-home treatments or IV ketamine therapy, Horizon dose ketamine rapidly relieves depression and anxiety symptoms. However, Horizon-range dosages don’t cause the same intense dissociation and side effects associated with higher doses.

Horizon ketamine doses optimize the window between microdosing and higher-dose treatments, providing rapid symptom relief and meaningful therapeutic benefits without intense psychoactive effects. This mid-range approach allows new and more experienced users to incorporate effective ketamine treatments into daily life on their own terms. Horizon doses gently catalyze positive shifts in perspective that can lead to greater self-awareness, fewer negative thoughts, and a deeper sense of inner peace.

Explore the science of ketamine

Because Mindscape Rx utilizes mid-dose ketamine, the effects are subtle, and there is no need for a sitter or guide during your session. You can safely administer the treatment on your own.

Most people notice a gentle relaxation and a subtle shift in perspective shortly after taking their medication. Horizon ketamine doses are moderate and typically don’t produce hallucinations or overwhelming effects. Many users feel more centered, less anxious, and more mentally clear, but some people say they feel tipsy or have a light “buzz.” You can manage the effects of your treatment comfortably at home, but make sure you don’t have to drive anywhere for at least 2 hours.

Oral troches provide a slower, steadier release taking effect over 15-30 minutes. Nasal spray is rapidly absorbed through the nasal mucosa, taking effect in about 5-10 minutes.

The effects of ketamine typically peak in 30-45 minutes after administration and may last between 1-2 hours overall.

No, we do not provide prescriptions for Spravato.

Spravato is an FDA-approved nasal spray that contains esketamine, a medication that is chemically related to ketamine but has a distinct chemical structure. Mindscape Rx provides oral and intranasal ketamine only.

Ketamine troches can be flavored to mask the bitter taste. Our troches are tropical fruit flavored by default, but you can request a different flavor or unflavored troches. Our nasal sprays are unflavored.

Some users describe the taste of nasal ketamine as bitter. Patient reports generally indicate it is an acquired taste which they become accustomed to with more frequent use.

At moderate doses, ketamine side effects are rare. However, side effects such as mild dizziness, nausea, or fatigue may occur. These typically resolve quickly. If you do experience any side effects during ketamine treatment, please contact our support team.

With regular use over time, raising your ketamine dose may be required to achieve therapeutic effects. If you think you’re developing a tolerance, you can discuss this with your medical provider. Your provider may recommend a change in your dosing schedule or raise your ketamine dose if appropriate. Dosages can only be changed by the prescribing provider.

Mindscape Rx offers oral ketamine in the form of troches, small lozenges that dissolve between the cheek and gums. We also offer nasal sprays that contain both ketamine and oxytocin. Both modalities have low and mid-dose options.

For more medication information, see our Program page.

Some medications, including many common antidepressants, are safe to use while using at-home ketamine therapy. You should refrain from taking benzodiazepines (Ativan, Xanax, etc.) and stimulant medications (Adderall, Ritalin, etc.) for 24 hours before ketamine treatment.

Certain medications, however, aren’t recommended due to safety concerns. It’s important to discuss any drugs you currently take or might take in the next year during your consultation.

Ketamine therapy is very effective when combined with psychotherapy. A therapist can help you integrate the insights discovered in your ketamine sessions, so they make a lasting impact on long-term thoughts and behaviors.

That said, ketamine therapy can also be effective for depression and anxiety, even if you don’t work with a therapist. Personal practices such as journaling, drawing, and meditation can also help you integrate your ketamine experiences for long-term success.

At this time, Mindscape Rx does not provide psychotherapy or referrals, but you can find helpful information and resources regarding psychotherapy and integration practices on our blog and in the premium member area. (coming soon!).

Horizon-range ketamine is safe for daily use, but some people find that less frequent treatments work well for them. After your telehealth consultation, your medical consultant will recommend a starting dose and suggest a treatment plan to meet your individual needs and goals.

Some people continue ketamine therapy for years. You and your provider can determine if and when it’s time to discontinue use. Withdrawal symptoms are rare with lower doses.

The only exception would be if you developed a medical condition that’s contraindicated for ketamine treatment, such as pregnancy or epilepsy.

Ketamine has been used safely in hospitals for decades as an anesthetic. Administered at lower doses under medical supervision, ketamine therapy is considered safe for at-home use. At Mindscape Rx, your Horizon dose is tailored to your specific needs and prescribed by licensed medical providers.

Read more about ketamine safety

Ketamine is a legal medication that’s FDA-approved as an anesthetic. In the U.S., a licensed medical provider can legally prescribe ketamine “off-label” to address anxiety and depression. Prescribing ketamine via telehealth and delivering it for at-home use is legal in all states served by our program. Mindscape Rx operates in full compliance with all applicable laws and regulations.

Yes, you can legally carry your prescribed ketamine medication anywhere within the U.S. when traveling. Be sure to keep the medication in its original packaging with the prescription label.

Ketamine has been FDA-approved for use as an anesthetic for decades. Research into mental health applications is ongoing, so ketamine is not yet approved by the FDA for the treatment of mental health conditions.

Licensed healthcare providers can legally prescribe ketamine for “off-label” use in addressing mental health-related symptoms.

Spravato, a nasal spray containing esketamine, has been FDA-approved to treat treatment-resistant depression and acute suicidal behavior​. Esketamine is similar to ketamine, but they’re not the same medication. Mindscape Rx provides oral and intranasal ketamine. We do not provide prescriptions for Spravato.

To begin your journey, simply fill out our online questionnaire and schedule a telehealth consultation with one of our licensed medical providers. Most people speak with a provider within 24-48 hours.

During your consultation, a licensed medical provider will discuss your physical and mental health history, treatment goals, and any concerns you may have. They will then customize your Horizon ketamine dose to address your specific needs. This consultation is risk-free, meaning you won’t be charged if you are not a suitable candidate for ketamine therapy.

Once prescribed, your Mindscape Rx prescription will be delivered directly to your doorstep within 3-5 business days.

You will be contacted when it’s time for a follow up. In the meantime, if you have questions or concerns, you can contact your provider via the member portal, where you can also request dose adjustments.

You can reach our customer support team via email at support@mindscaperx.com. Members may use the contact information provided in the member area.

You can find detailed plan and pricing information on our Program page.

Mindscape Rx is not in-network with any insurance plan at this time. Currently, most insurers do not cover ketamine therapy. We recommend checking with your insurance provider to understand your coverage options.

You can cancel your subscription any time before your next refill via the member portal.

Your initial consultation is risk-free. At the time of booking, we’ll put a hold on your credit card in the amount of the monthly subscription fee. If, during your consultation, your provider determines that you’re ineligible for ketamine therapy due to a health contraindication, we will release the hold, and your card will not be charged.

Once you’re approved for the program, your card will be charged, and your prescription will be processed. This payment is non-refundable, but you may cancel your subscription, free of charge, before your next refill is processed.

Please visit our Program page for more information.